Skip to content

Blog Header

Caspase Detection

Apr 30, 2013
Cancer Research
Congratulations to the ChEMTox lab at Universidad Metropolitana, directed by Dr. Beatriz Zayas, for publishing their evaluation of nitrobenzazolo [3,2-a]quinolinium salts as potential anticancer agents!  To assess apoptosis, the activation of caspases 3 & 7 in the A431 epidermoid...
Nov 29, 2012
News
As part of our product development efforts to supply high quality apoptosis detection and caspase assays to the global research market, ImmunoChemistry Technologies has decided to discontinue offering the sulforhodamine-labeled FLICA caspase 3/7 inhibitor reagent, SR-DEVD-FMK (part number 678)....
Jul 16, 2012
New Products
MINNEAPOLIS, Minnesota (July 16, 2012) - ICT is pleased to announce the release of a far-red fluorescent caspase assay for in vitro apoptosis detection via activated caspase enzymes. FLICA® 660 Poly Caspase Assay This in vitro caspase assay employs the new far-red fluorescent...
May 25, 2012
New Products
ICT is pleased to announce the release of a far-red fluorescence-emitting inhibitor probe for the in vitro detection of activated caspase-1 (ICE) enzyme. FLICA® 660 Caspase-1 Assay This in vitro assay employs the new far-red fluorescent caspase-1 inhibitor probe, FLICA 660-YVAD-FMK, to detect...
Mar 20, 2012
Caspase Detection
ICT is pleased to announce the upcoming release of a far-red fluorescence-emitting inhibitor probe for the in vitro detection of activated caspase-1 (ICE) enzyme. FLICA™ 660 Caspase-1 Detection Reagent, 660-YVAD-FMK, allows for the rapid and reliable detection of caspase-1 in whole, living...
Feb 17, 2012
Caspase-1
Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epitheliaLeigh A. Knodler, Bruce A. Vallance, Jean Celli, Seth Winfree, Bryan Hansen, Marinieve Montero, and Olivia Steele-MortimerPNAS. 2010; 107:17733-17738. [Abstract] For determination of activated caspase-1 and...
Oct 17, 2011
Caspase Detection
Magic Red™ Caspase-3/7 detection assays measure apoptosis-associated DEVDase enzyme activity in living, intact cells. View a time-lapse movie of caspase-3/7 activation in cultured rat fibroblasts. Data courtesy of Dr. Martin Purschke, MA General Hospital. Windows Media Player or similar...
Sep 20, 2011
Caspase Detection
Caspase-1 (ICE) • Originally identified as Interleukin -1β Converting Enzyme or ICE • Cleaves IL-1 beta and IL-18 into active forms • Creation of the inflammasome during host responses to pathogens leads to the activation of caspase-1 • Active caspase-1 plays an antimicrobial role during...
Aug 23, 2011
FLICA
Apoptosis is an evolutionarily conserved form of cell suicide responsible for various biological processes including the normal turnover of cells and the proper functioning of the immune system. This process of shutting down old, diseased, or otherwise disfunctional cells is mediated by a cascade...