Cytotoxicity Testing

Cytotoxicity Assay Kits and Reagents for Cytotoxicity Studies

 

Kits

 

Cytotoxicity Assays for Cell-mediated Cytotoxicity Studies

Our cytotoxicity testing assays were developed to assess cell-mediated cytotoxicity via flow cytometry without the use of radiological isotopes.

The Basic Cytotoxicity Test Kit is a flow-based assay for assessing cell-mediated necrosis by detecting membrane-permeable cells after two cell populations (target and effector) are combined.

The Total Cytotoxicity Test Kit assesses two key parameters of cell-mediated cytotoxicity, apoptosis and necrosis, in a single-tube assay format for analysis by flow cytometry.

 

Cellular
Stains

 

Rapidly stain dead or permeabilized cells with these live/dead stains:

DRAQ7 Far-Red Live-Cell Impermeant Dye
7-AAD Red Fluorescent Live/Dead Stain
Propidium Iodide Red Fluorescent Live/Dead Stain

Additional cellular stains, like CFSE green membrane stain, are available to supplement our assay kits or to create custom assays.

Apoptosis-Inducing Chemicals

  Camptothecin: A cytotoxic plant alkaloid with antitumor properties, Camptothecin is a prototypic DNA topoisomerase I inhibitor.

Staurosporine: Isolated from Streptomyces sp., Staurosporine is a protein kinase inhibitor. Staurosporine induces DNA fragmentation and apoptosis at 1µM in 2-3 hours.

Product Catalog: Apoptosis Assays Application Guide

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