Detection Reagents

Fluorescent Probes to Detect Apoptosis, Caspase Activity, Mitochondrial Permeability

ICT develops and supplies fluorescent detection reagents for in vivo and in vitro life science research studies to investigate biological systems and the effects of disease and treatment. ICT’s fluorescent detection reagents are presently used in animal models and cultured (in vitro) cell and tissue samples to assess a wide range of cell and disease-state pathologies including: apoptosis, necrosis, cytotoxicity, oxidative stress, cancer, and neurodegeneration, among other applications. Example uses of ICT's fluorescent detection reagents:

• Assess the effectiveness of chemotherapy: is the treatment killing tumor cells without harming non-cancerous cells?
• Quantify neurodegeneration: is a disease, such as Alzheimer’s, causing brain cells to die?
• Detect eye disease before vision loss: are retinal cells abnormally dying due to diabetes or another condition?

in vitro apoptosis and protease detection and cellular imaging

ICT's specialty in vitro fluorescent protease and apoptosis detection assays were designed for use with cultured cells and tissues to detect apoptosis, active caspases, cathepsins, serine proteases, and assess mitochondrial health in isolated cell lines.

in vivo apoptosis detection and imaging

FLIVO™ in vivo Apoptosis assays are used with live animal models to assess in vivo apoptosis and study the effectiveness of treatment or the effects of disease.

All products are currently for research use only. Once approved for human clinical use, ICT’s products may be used to better manage disease and personalize treatment.